Protoporphyrinogen IX biosynthetic process

Across TCGA cell cohorts, RNA activity of the Protoporphyrinogen IX biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPOX, CYB561, and RPL18A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protoporphyrinogen IX biosynthetic process activity versus CPOX in BREAST (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CPOX →	+1.176	+0.867	<.001	.004	2	9
BLOOD_Leukemia	CYB561 →	+2.226	+1.363	<.001	<.001	3	4
LARGE_INTESTINE	RPL18A →	+0.388	+0.680	.008	.004	3	4
BLOOD_Leukemia	SEPTIN9 →	-1.314	-0.776	<.001	.002	3	4
BLOOD_Leukemia	ICAM5 →	+2.092	+0.983	<.001	<.001	3	4
BLOOD_Leukemia	STARD8 →	+1.649	+1.009	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006782 vs CPOX — BREAST

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