Porphyrin-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Porphyrin-containing compound metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBAP2L, NUFIP2, and PPP1R9A_S840, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Porphyrin-containing compound metabolic process activity versus UBAP2L in UCEC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBAP2L →	+0.268	+0.042	<.001	.004	3	5
CCRCC	NUFIP2 →	+0.183	+0.030	<.001	<.001	3	5
COAD	PPP1R9A_S840 →	+0.667	+0.024	<.001	<.001	3	5
LUAD	FLNB_S2532 →	-0.593	-0.043	.001	<.001	3	5
LSCC	KIF1A_S1370 →	+1.701	+0.046	.002	<.001	3	5
LUAD	PRR14_T363 →	-0.534	-0.036	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006778 vs UBAP2L — UCEC

Explore this scatter interactively →