Porphyrin-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Porphyrin-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAUS1, ZNHIT3, and NUDT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Porphyrin-containing compound metabolic process activity versus HAUS1 in GBM (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HAUS1 →	-0.472	-0.164	.002	<.001	3	5
GBM	ZNHIT3 →	-0.242	-0.133	<.001	<.001	3	5
GBM	NUDT1 →	-0.339	-0.137	<.001	<.001	3	4
UCEC	STAG1 →	-0.732	-0.276	.001	<.001	3	4
GBM	MRPS26 →	-0.371	-0.125	<.001	.003	3	4
LSCC	DNAJC8 →	-0.258	-0.107	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006778 vs HAUS1 — GBM

Explore this scatter interactively →