Porphyrin-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Porphyrin-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMP6, AHNAK2, and FAM214B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BMP6 grouped by Porphyrin-containing compound metabolic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	BMP6 →	+2.761	+1.530	.001	<.001	3	4
LARGE_INTESTINE	AHNAK2 →	-2.209	-0.748	<.001	.006	3	4
OVARY	FAM214B →	-0.774	-1.379	.003	<.001	3	4
KIDNEY	GPR68 →	-1.136	-1.361	.002	<.001	3	4
LUNG_SCLC	ENDOV →	-0.681	-1.495	.008	<.001	3	4
LUNG_SCLC	CEBPD →	-1.274	-1.189	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMP6 by Porphyrin-containing compound metabolic process activity — SOFT_TISSUE

Explore this box plot interactively →