Porphyrin-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Porphyrin-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPRTN, EEF1B2, and G6PD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Porphyrin-containing compound metabolic process activity versus SPRTN in BREAST (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SPRTN →	-0.529	-0.182	<.001	.001	3	4
BREAST	EEF1B2 →	-0.764	-0.257	.001	<.001	3	4
BREAST	G6PD →	+1.317	+0.205	.007	.002	3	4
BREAST	SMIM14 →	+1.469	+0.195	.001	.006	3	4
BREAST	DUSP7 →	-0.776	-0.190	.003	.001	3	4
BREAST	OXCT2 →	-0.757	-0.222	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006778 vs SPRTN — BREAST

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