Vitamin A metabolic process

Across TCGA patient cohorts, RNA activity of the Vitamin A metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBP1, MFN1, and RHOG, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin A metabolic process activity versus RBP1 in COAD (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RBP1 →	+1.424	+0.140	<.001	<.001	3	8
BRCA	MFN1 →	+0.249	+0.076	<.001	<.001	3	5
LSCC	RHOG →	-0.202	-0.076	.003	.009	3	4
GBM	ZBTB7A →	-0.204	-0.069	.004	<.001	3	4
LSCC	CTPS2 →	+0.215	+0.082	.009	.004	2	5
LUAD	PEAK1_T813 →	+0.808	+0.113	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006776 vs RBP1 — COAD

Explore this scatter interactively →