Vitamin A metabolic process

Across TCGA cell cohorts, RNA activity of the Vitamin A metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPBP1, IL17D, and FKTN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPBP1 grouped by Vitamin A metabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GPBP1 →	-0.481	-1.214	.005	.003	3	4
BONE	IL17D →	-1.312	-1.586	.002	.001	2	5
BLOOD_Leukemia	FKTN →	-0.777	-1.349	.002	.002	3	4
BLOOD_Leukemia	NFYB →	-0.683	-1.234	.004	.002	3	4
BLOOD_Leukemia	LTB4R2 →	-1.234	-1.075	<.001	.003	3	4
BLOOD_Myeloma	USP28 →	+0.622	+1.795	.009	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPBP1 by Vitamin A metabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →