Vitamin A metabolic process

Across TCGA cell cohorts, RNA activity of the Vitamin A metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBP1, SOWAHA, and FRAS1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin A metabolic process activity versus RBP1 in LUNG_NSCLC_LUSC (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RBP1 →	+5.306	+2.159	<.001	<.001	3	16
OVARY	SOWAHA →	+0.771	+1.276	<.001	<.001	3	8
LIVER	FRAS1 →	+2.421	+1.401	<.001	<.001	3	7
SOFT_TISSUE	MPG →	-1.170	-1.613	<.001	<.001	3	7
OVARY	ERLIN1 →	-0.808	-1.160	.009	.004	3	7
LIVER	MDK →	+3.006	+1.731	.004	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006776 vs RBP1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →