Riboflavin metabolic process

Across TCGA patient cohorts, RNA activity of the Riboflavin metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZNF622_S143, DDX21, and EIF4B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Riboflavin metabolic process activity versus ZNF622_S143 in LSCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZNF622_S143 →	+0.662	+0.064	.001	.002	3	6
LUAD	DDX21 →	+0.362	+0.091	.001	<.001	3	6
LUAD	EIF4B →	+0.192	+0.069	<.001	<.001	3	6
LUAD	PPP1R10 →	+0.189	+0.075	.003	.008	3	6
LSCC	TBCEL →	-0.187	-0.064	.002	<.001	3	6
CCRCC	KIF21A →	+0.238	+0.056	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006771 vs ZNF622_S143 — LSCC

Explore this scatter interactively →