Riboflavin metabolic process

Across TCGA patient cohorts, RNA activity of the Riboflavin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITM2A, MMRN1, and CMAHP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Riboflavin metabolic process activity versus ITM2A in OV (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ITM2A →	-0.981	-0.129	<.001	<.001	3	4
UCEC	MMRN1 →	-0.992	-0.140	.002	.004	3	4
HNSC	CMAHP →	-0.524	-0.154	.008	.001	3	4
HNSC	GPIHBP1 →	-0.730	-0.152	.005	.004	3	4
UCEC	ESRP1 →	+0.555	+0.161	.006	.002	3	3
PDAC	TRMT2B-AS1 →	+0.749	+0.142	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006771 vs ITM2A — OV

Explore this scatter interactively →