Riboflavin metabolic process

Across TCGA cell cohorts, RNA activity of the Riboflavin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAF, ANKRD13D, and RNF170, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OAF grouped by Riboflavin metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OAF →	-1.048	-0.792	.008	.006	3	4
BLOOD_Leukemia	ANKRD13D →	-1.191	-1.679	.003	<.001	3	4
SKIN	RNF170 →	-0.674	-1.110	.002	.003	3	4
LARGE_INTESTINE	ARHGEF17 →	-2.093	-1.393	.001	.007	3	3
LARGE_INTESTINE	MIDEAS →	-0.941	-1.048	.006	.005	3	3
LARGE_INTESTINE	REEP3 →	-0.923	-1.586	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OAF by Riboflavin metabolic process activity — CNS

Explore this box plot interactively →