Riboflavin metabolic process

Across TCGA cell cohorts, RNA activity of the Riboflavin metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC23B, PTPN5, and PRPF40B, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEC23B grouped by Riboflavin metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SEC23B →	+0.125	+1.991	.007	.004	3	1
BREAST	PTPN5 →	-0.183	-1.897	<.001	<.001	3	1
BREAST	PRPF40B →	-0.188	-1.897	.006	<.001	3	1
BREAST	GPR63 →	-0.194	-1.897	.006	<.001	3	1
BREAST	ATP6V0E1 →	-0.175	-1.897	.003	<.001	3	1
BREAST	TOMM40 →	-0.542	-1.897	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEC23B by Riboflavin metabolic process activity — BREAST

Explore this box plot interactively →