Vitamin metabolic process

Across TCGA patient cohorts, RNA activity of the Vitamin metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TAPT1_S523, SEPTIN8, and CBR1_S151, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin metabolic process activity versus TAPT1_S523 in UCEC (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TAPT1_S523 →	-1.073	-0.047	<.001	.006	3	6
LUAD	SEPTIN8 →	-0.250	-0.035	<.001	<.001	3	5
LSCC	CBR1_S151 →	+1.013	+0.024	.004	.001	3	5
BRCA	HDGFL3 →	-0.569	-0.014	.003	.008	3	5
OV	GPALPP1 →	-0.356	-0.017	.003	.003	2	6
CCRCC	PPIF →	+0.385	+0.033	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006766 vs TAPT1_S523 — UCEC

Explore this scatter interactively →