Vitamin metabolic process

Across TCGA cell cohorts, RNA activity of the Vitamin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FHL1, CCDC82, and ATAD3A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FHL1 grouped by Vitamin metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FHL1 →	+2.054	+0.868	<.001	<.001	3	5
BREAST	CCDC82 →	+1.511	+0.809	<.001	<.001	3	4
SKIN	ATAD3A →	+0.682	+0.768	.004	.007	3	4
SKIN	PIGS →	-0.668	-1.136	.001	<.001	3	4
BREAST	HIP1R →	-1.113	-0.887	.001	.002	3	4
LUNG_SCLC	RALGPS2 →	-1.528	-0.681	.008	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FHL1 by Vitamin metabolic process activity — BREAST

Explore this box plot interactively →