Folic acid-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Folic acid-containing compound metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIP13, CDC20_T70, and XPO5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Folic acid-containing compound metabolic process activity versus TRIP13 in LUAD (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TRIP13 →	+0.713	+0.045	<.001	<.001	3	7
OV	CDC20_T70 →	+0.903	+0.044	.002	.001	3	7
LSCC	XPO5 →	+0.413	+0.032	.002	.004	3	7
UCEC	RRM2 →	+0.771	+0.056	<.001	<.001	3	6
OV	TPX2_S486 →	+0.737	+0.034	<.001	<.001	3	6
OV	CDK1 →	+0.751	+0.047	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006760 vs TRIP13 — LUAD

Explore this scatter interactively →