Folic acid-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Folic acid-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC12A, PLEK, and PLA2G7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Folic acid-containing compound metabolic process activity versus CLEC12A in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CLEC12A →	+0.615	+0.148	.001	.004	3	4
BRCA	PLEK →	+0.797	+0.167	<.001	.002	3	3
BRCA	PLA2G7 →	+0.747	+0.140	<.001	.001	3	3
BRCA	USP6NL →	+0.493	+0.156	<.001	<.001	3	3
BRCA	SCIMP →	+0.386	+0.124	<.001	.005	3	3
LSCC	CLEC4D →	+0.512	+0.211	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006760 vs CLEC12A — BRCA

Explore this scatter interactively →