Folic acid-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Folic acid-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHSY1, ANGPT1, and IMPA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHSY1 grouped by Folic acid-containing compound metabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CHSY1 →	-0.734	-1.301	.004	<.001	3	5
BONE	ANGPT1 →	-1.607	-1.841	.002	<.001	3	5
BLOOD_Myeloma	IMPA2 →	+2.497	+1.788	.001	<.001	3	4
LUNG_NSCLC_LUSC	MPRIP →	-0.994	-0.997	.002	.009	3	4
CNS	GATA3 →	-1.039	-0.713	.003	.001	3	4
CNS	AJUBA →	-1.141	-0.771	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHSY1 by Folic acid-containing compound metabolic process activity — PANCREAS

Explore this box plot interactively →