Folic acid-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Folic acid-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRR1, PRPF39, and TDP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Folic acid-containing compound metabolic process activity versus KRR1 in BREAST (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KRR1 →	+0.652	+0.186	.002	<.001	3	5
BLOOD_Leukemia	PRPF39 →	+0.474	+0.173	.007	.006	3	5
BLOOD_Leukemia	TDP1 →	+0.440	+0.133	.001	.009	3	5
BLOOD_Leukemia	UBR7 →	+0.548	+0.185	.001	<.001	3	5
BLOOD_Leukemia	RAPGEF6 →	+0.434	+0.137	.005	.007	3	5
LARGE_INTESTINE	ADAT2 →	+0.982	+0.225	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006760 vs KRR1 — BREAST

Explore this scatter interactively →