ATP biosynthetic process

Across TCGA patient cohorts, RNA activity of the ATP biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRRM2_S536, EEF2_S502, and CD276, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ATP biosynthetic process activity versus SRRM2_S536 in COAD (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SRRM2_S536 →	-0.451	-0.012	.001	.009	3	6
CCRCC	EEF2_S502 →	-0.774	-0.034	.001	.003	3	5
GBM	CD276 →	-0.399	-0.049	<.001	<.001	3	4
GBM	CRTAP →	-0.509	-0.047	.001	<.001	3	4
GBM	FOSL2_S120 →	-0.574	-0.036	<.001	.002	3	4
LSCC	MPP7 →	+0.513	+0.028	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006754 vs SRRM2_S536 — COAD

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