ATP biosynthetic process

Across TCGA patient cohorts, RNA activity of the ATP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCN1, HNRNPLL, and EML4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ATP biosynthetic process activity versus RCN1 in LSCC (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCN1 →	-0.600	-0.168	<.001	<.001	3	5
LSCC	HNRNPLL →	-0.246	-0.123	<.001	<.001	3	5
LSCC	EML4 →	-0.276	-0.150	.004	.001	3	5
UCEC	APAF1 →	-0.450	-0.225	.008	<.001	3	5
UCEC	TMSB10 →	-0.645	-0.167	<.001	<.001	3	5
PDAC	CCDC88A →	-0.340	-0.143	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006754 vs RCN1 — LSCC

Explore this scatter interactively →