ATP biosynthetic process

Across TCGA cell cohorts, RNA activity of the ATP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF107, NCAPG, and B4GALT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ATP biosynthetic process activity versus ZNF107 in BLOOD_Leukemia (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF107 →	-1.060	-0.258	.002	<.001	3	6
BLOOD_Leukemia	NCAPG →	-0.902	-0.264	<.001	.001	3	6
SOFT_TISSUE	B4GALT2 →	-0.711	-0.436	.003	.002	3	5
OVARY	C2orf72 →	+2.042	+0.276	.003	.001	3	5
BLOOD_Lymphoma	SPATA17 →	+0.573	+0.200	.007	.006	3	5
LUNG_NSCLC_LUAD	TACC3 →	-0.544	-0.170	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006754 vs ZNF107 — BLOOD_Leukemia

Explore this scatter interactively →