Glutathione catabolic process

Across TCGA patient cohorts, RNA activity of the Glutathione catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHAC1, GGT1, and GGT5, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutathione catabolic process activity versus CHAC1 in UVM (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	CHAC1 →	+2.556	+0.060	<.001	<.001	3	28
UCS	GGT1 →	+1.823	+0.084	<.001	<.001	3	21
ACC	GGT5 →	+1.399	+0.057	<.001	.001	3	21
BLCA	PTGIR →	+0.456	+0.043	<.001	<.001	3	16
ESCA	ADM2 →	+0.911	+0.059	<.001	<.001	3	16
READ	PDGFRB →	+0.880	+0.046	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006751 vs CHAC1 — UVM

Explore this scatter interactively →