Glutathione catabolic process

Across TCGA patient cohorts, RNA activity of the Glutathione catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ASNS, CGN_S338, and NSMCE3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutathione catabolic process activity versus ASNS in LSCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ASNS →	+0.440	+0.072	.003	.004	3	4
LSCC	CGN_S338 →	-0.778	-0.091	.002	<.001	3	4
LSCC	NSMCE3 →	+0.237	+0.089	<.001	<.001	3	4
OV	GARS1 →	+0.294	+0.076	<.001	<.001	3	4
LUAD	AARS1 →	+0.305	+0.089	<.001	<.001	3	4
LSCC	FAAH →	-0.500	-0.125	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006751 vs ASNS — LSCC

Explore this scatter interactively →