Glutathione catabolic process

Across TCGA cell cohorts, RNA activity of the Glutathione catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MASP2, ROR2, and NQO1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MASP2 grouped by Glutathione catabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MASP2 →	-0.432	-1.710	.006	.004	3	2
LARGE_INTESTINE	ROR2 →	+0.337	+1.793	.006	.009	3	2
BREAST	NQO1 →	+0.406	+2.141	.007	<.001	3	2
LUNG_NSCLC_LUAD	FPR2 →	-0.216	-2.431	.002	.002	3	2
SKIN	LIMCH1 →	-0.090	-2.524	.003	.002	2	2
LUNG_NSCLC_LUAD	MKNK2 →	+0.161	+2.047	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MASP2 by Glutathione catabolic process activity — BREAST

Explore this box plot interactively →