Glutathione catabolic process

Across TCGA cell cohorts, RNA activity of the Glutathione catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SETSIP, SPTB, and SLC9A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutathione catabolic process activity versus SETSIP in LUNG_NSCLC_LUAD (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SETSIP →	-0.585	-1.921	.001	<.001	3	4
LARGE_INTESTINE	SPTB →	-1.914	-1.743	.005	.001	3	2
LUNG_NSCLC_LUAD	SLC9A1 →	-1.422	-1.983	<.001	.005	3	2
LUNG_NSCLC_LUAD	RASL11B →	-0.553	-2.232	<.001	.001	3	2
LUNG_NSCLC_LUAD	USP20 →	-0.822	-1.968	<.001	.005	3	2
LUNG_NSCLC_LUAD	PABPC3 →	-0.334	-1.651	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006751 vs SETSIP — LUNG_NSCLC_LUAD

Explore this scatter interactively →