Glutathione metabolic process

Across TCGA patient cohorts, RNA activity of the Glutathione metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPR, GSTM3, and MTIF2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutathione metabolic process activity versus SPR in LSCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPR →	+0.341	+0.051	<.001	<.001	3	7
LSCC	GSTM3 →	+1.473	+0.057	<.001	<.001	3	7
LSCC	MTIF2 →	+0.254	+0.038	<.001	<.001	3	7
HNSC	TACC2_S41 →	+0.881	+0.067	.001	.001	3	6
COAD	MIA3 →	+0.311	+0.022	.001	.009	3	6
OV	DARS2 →	+0.405	+0.032	.006	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006749 vs SPR — LSCC

Explore this scatter interactively →