Glutathione metabolic process

Across TCGA patient cohorts, RNA activity of the Glutathione metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF2, ABCA8, and SLC8A3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutathione metabolic process activity versus KLF2 in LUAD (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KLF2 →	+0.650	+0.147	.001	.001	3	4
HNSC	ABCA8 →	+0.839	+0.110	.001	.004	3	4
UCEC	SLC8A3 →	+0.366	+0.075	.007	.006	3	4
BRCA	IL1RL1 →	+0.439	+0.145	.004	.001	3	4
BRCA	MYH11 →	+1.272	+0.186	<.001	<.001	3	4
BRCA	KLHL3 →	+0.801	+0.176	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006749 vs KLF2 — LUAD

Explore this scatter interactively →