Glutathione metabolic process

Across TCGA cell cohorts, RNA activity of the Glutathione metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSR, PHLDB2, and COQ2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutathione metabolic process activity versus GSR in BREAST (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GSR →	+1.316	+0.466	<.001	<.001	3	6
STOMACH	PHLDB2 →	-3.969	-0.528	<.001	.001	3	5
BLOOD_Leukemia	COQ2 →	+1.027	+0.166	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	METTL5 →	+0.618	+0.270	.002	.001	3	5
SKIN	ASAH1 →	+2.371	+0.519	<.001	<.001	3	5
LUNG_SCLC	DNAH5 →	-0.721	-0.216	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006749 vs GSR — BREAST

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