Ubiquinone metabolic process

Across TCGA patient cohorts, RNA activity of the Ubiquinone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F10, ADORA1, and ESM1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquinone metabolic process activity versus F10 in CCRCC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	F10 →	+1.061	+0.124	.004	.006	3	3
HNSC	ADORA1 →	+0.324	+0.089	.009	.009	3	3
BRCA	ESM1 →	-0.838	-0.136	.003	.008	3	3
HNSC	LRRN2 →	+0.627	+0.157	.002	.001	3	3
HNSC	ZDHHC13 →	-0.635	-0.191	<.001	<.001	3	3
HNSC	METTL7A →	+0.941	+0.149	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006743 vs F10 — CCRCC

Explore this scatter interactively →