Ubiquinone metabolic process

Across TCGA cell cohorts, RNA activity of the Ubiquinone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LOXL4, USP3, and GAB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LOXL4 grouped by Ubiquinone metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LOXL4 →	-1.075	-0.653	.003	.003	3	5
BREAST	USP3 →	+0.602	+0.911	.003	.002	3	5
BLOOD_Leukemia	GAB1 →	+2.147	+1.273	.008	.001	3	4
BLOOD_Leukemia	NCOA2 →	+0.882	+1.170	.007	.001	3	4
BLOOD_Leukemia	MYSM1 →	+0.746	+0.887	.009	.002	3	4
BLOOD_Leukemia	MBNL3 →	+1.098	+0.780	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LOXL4 by Ubiquinone metabolic process activity — OVARY

Explore this box plot interactively →