Ubiquinone metabolic process

Across TCGA cell cohorts, RNA activity of the Ubiquinone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FDXR, MCRIP2, and CEP57, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquinone metabolic process activity versus FDXR in OVARY (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FDXR →	+1.760	+1.176	<.001	<.001	3	10
LUNG_SCLC	MCRIP2 →	+1.088	+1.212	.006	.007	3	5
BREAST	CEP57 →	-0.610	-0.755	.005	<.001	3	5
SOFT_TISSUE	TEDC2 →	-1.194	-1.924	.004	<.001	3	5
LIVER	FANCG →	-1.184	-1.733	<.001	<.001	3	5
CNS	ANTKMT →	+1.037	+1.173	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006743 vs FDXR — OVARY

Explore this scatter interactively →