NADPH regeneration

Across TCGA patient cohorts, RNA activity of the NADPH regeneration pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PYCR2, MAP1B_S1378, and MINK1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NADPH regeneration activity versus PYCR2 in HNSC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PYCR2 →	+0.398	+0.063	.003	.003	3	4
LSCC	MAP1B_S1378 →	+0.999	+0.051	<.001	<.001	3	4
LSCC	MINK1 →	-0.177	-0.035	.009	.008	3	4
OV	G6PD →	+0.334	+0.046	.005	<.001	3	4
UCEC	TPD52L2_S186 →	+0.419	+0.058	<.001	.008	3	3
UCEC	USP13 →	+0.299	+0.058	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006740 vs PYCR2 — HNSC

Explore this scatter interactively →