NADPH regeneration

Across TCGA patient cohorts, RNA activity of the NADPH regeneration pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCR2, P2RX1, and CCT7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NADPH regeneration activity versus CXCR2 in GBM (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CXCR2 →	+0.660	+0.089	.002	.006	3	4
PDAC	P2RX1 →	+0.705	+0.146	<.001	<.001	3	4
PDAC	CCT7 →	-0.210	-0.157	.006	<.001	3	4
GBM	PBK →	-1.101	-0.101	<.001	.001	3	4
PDAC	TRBV4-2 →	+0.458	+0.139	.003	<.001	3	4
GBM	DHFR →	-0.672	-0.114	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006740 vs CXCR2 — GBM

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