NADPH regeneration

Across TCGA cell cohorts, RNA activity of the NADPH regeneration pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGD, GSR, and G6PD, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NADPH regeneration activity versus PGD in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PGD →	+1.767	+0.527	<.001	<.001	3	9
LUNG_NSCLC_LUAD	GSR →	+1.625	+0.339	<.001	.002	3	8
LUNG_NSCLC_LUAD	G6PD →	+1.725	+0.294	<.001	.003	3	7
LUNG_NSCLC_LUAD	SEMA7A →	-2.534	-0.331	<.001	<.001	3	6
LUNG_NSCLC_LUAD	TALDO1 →	+0.877	+0.303	.001	.003	3	6
BREAST	OSGIN1 →	+1.674	+0.332	.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006740 vs PGD — UPPER_AERODIGESTIVE_TRACT

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