NADP metabolic process

Across TCGA cell cohorts, RNA activity of the NADP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPA4, ARIH1, and NUPR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPA4 grouped by NADP metabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CPA4 →	-3.780	-1.695	<.001	<.001	3	4
BLOOD_Leukemia	ARIH1 →	-0.684	-1.039	.003	.006	3	4
LIVER	NUPR1 →	-2.733	-1.137	.007	<.001	3	4
BREAST	ATL1 →	-1.284	-0.834	<.001	<.001	3	4
SOFT_TISSUE	APOBEC3H →	+0.448	+1.476	<.001	<.001	3	3
SOFT_TISSUE	AEBP1 →	-3.259	-1.151	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPA4 by NADP metabolic process activity — URINARY_TRACT

Explore this box plot interactively →