NADP metabolic process

Across TCGA cell cohorts, RNA activity of the NADP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are G6PD, GSR, and PGD, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NADP metabolic process activity versus G6PD in LUNG_NSCLC_LUAD (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	G6PD →	+1.445	+0.247	<.001	<.001	3	7
STOMACH	GSR →	+1.773	+0.316	<.001	.003	3	7
LUNG_NSCLC_LUAD	PGD →	+1.288	+0.336	.001	<.001	3	6
LIVER	SLC37A1 →	+1.895	+0.327	.002	.001	3	6
LUNG_NSCLC_LUAD	SELENBP1 →	+2.231	+0.286	.003	.001	3	6
BLOOD_Lymphoma	DSE →	-1.696	-0.199	.002	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006739 vs G6PD — LUNG_NSCLC_LUAD

Explore this scatter interactively →