One-carbon metabolic process

Across TCGA patient cohorts, RNA activity of the One-carbon metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT1E, TSPYL1, and MT1X, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, One-carbon metabolic process activity versus MT1E in PDAC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MT1E →	+0.511	+0.136	.009	.005	2	5
LUAD	TSPYL1 →	-0.325	-0.162	.004	.004	3	4
GBM	MT1X →	+1.393	+0.257	<.001	.003	3	4
GBM	MT1G →	+0.799	+0.245	.002	.001	3	4
GBM	LUCAT1 →	+1.188	+0.410	<.001	<.001	3	4
OV	SLC11A1 →	+0.421	+0.221	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006730 vs MT1E — PDAC

Explore this scatter interactively →