One-carbon metabolic process

Across TCGA cell cohorts, RNA activity of the One-carbon metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL2BP, UBE2A, and ZNF425, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARL2BP grouped by One-carbon metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ARL2BP →	-1.114	-1.246	.004	.004	3	4
LUNG_SCLC	UBE2A →	-0.682	-1.198	.007	.002	3	4
OESOPHAGUS	ZNF425 →	-1.306	-1.349	.005	.005	3	4
KIDNEY	ITGA6 →	+0.935	+1.112	.006	<.001	3	4
URINARY_TRACT	CDK17 →	-0.947	-1.478	.006	.006	3	4
LARGE_INTESTINE	LHFPL6 →	-1.314	-0.943	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARL2BP by One-carbon metabolic process activity — LUNG_SCLC

Explore this box plot interactively →