One-carbon metabolic process

Across TCGA cell cohorts, RNA activity of the One-carbon metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAFAH1B3, POLD3, and TSEN34, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, One-carbon metabolic process activity versus PAFAH1B3 in SKIN (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PAFAH1B3 →	-0.494	-0.169	.001	.001	3	5
LIVER	POLD3 →	+1.012	+0.271	.002	.005	3	5
SKIN	TSEN34 →	-0.440	-0.184	.009	<.001	3	4
SKIN	SPSB1 →	-1.286	-0.168	.001	.004	3	4
BLOOD_Lymphoma	PTPRB →	+0.632	+0.173	.007	.003	3	4
BREAST	CEP120 →	+0.634	+0.157	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006730 vs PAFAH1B3 — SKIN

Explore this scatter interactively →