Terpenoid metabolic process

Across TCGA cell cohorts, RNA activity of the Terpenoid metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEK7, MAPKAP1, and RBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEK7 grouped by Terpenoid metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NEK7 →	-0.277	-0.916	.003	.009	3	5
BONE	MAPKAP1 →	-0.372	-1.359	.009	.006	3	5
OVARY	RBP1 →	-0.392	-1.145	<.001	<.001	3	5
BREAST	ATG4D →	-0.203	-0.596	.007	.005	2	5
STOMACH	HK3 →	-0.148	-1.067	.005	.002	3	4
BLOOD_Leukemia	TM4SF4 →	+0.201	+1.525	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEK7 by Terpenoid metabolic process activity — LUNG_SCLC

Explore this box plot interactively →