Terpenoid metabolic process

Across TCGA cell cohorts, RNA activity of the Terpenoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are QPRT, ITPRIP, and MGAT4A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Terpenoid metabolic process activity versus QPRT in LIVER (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	QPRT →	+4.452	+0.206	<.001	.003	3	3
LIVER	ITPRIP →	-1.565	-0.225	.001	<.001	3	3
BREAST	MGAT4A →	+1.586	+0.264	.002	.001	3	3
BLOOD_Myeloma	ADGRA3 →	-1.834	-0.259	.004	.002	3	3
URINARY_TRACT	RASSF4 →	-1.822	-0.205	.003	.003	2	4
URINARY_TRACT	PCYT2 →	+1.462	+0.268	.005	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006721 vs QPRT — LIVER

Explore this scatter interactively →