Isoprenoid metabolic process

Across TCGA patient cohorts, RNA activity of the Isoprenoid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C3, AKR1B10, and AKR1C1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoprenoid metabolic process activity versus AKR1C3 in LSCC (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C3 →	+1.272	+0.044	<.001	<.001	3	8
LSCC	AKR1B10 →	+1.647	+0.040	<.001	<.001	3	6
LSCC	AKR1C1 →	+1.698	+0.046	<.001	<.001	3	6
UCEC	AKR1C2 →	+1.606	+0.028	.001	.008	3	6
OV	ADH1C →	+2.403	+0.028	<.001	<.001	3	6
LSCC	HTATIP2 →	+0.331	+0.035	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006720 vs AKR1C3 — LSCC

Explore this scatter interactively →