Isoprenoid metabolic process

Across TCGA patient cohorts, RNA activity of the Isoprenoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRIP1, TAF8, and DYM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoprenoid metabolic process activity versus BRIP1 in COAD (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BRIP1 →	-0.355	-0.196	.002	.002	3	4
COAD	TAF8 →	-0.274	-0.200	.008	.001	3	4
COAD	DYM →	-0.241	-0.198	.008	.001	3	4
PDAC	PRIM1 →	-0.315	-0.179	.006	.005	3	4
OV	KIAA0513 →	+0.577	+0.233	.002	.001	3	4
BRCA	SLPI →	+1.932	+0.168	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006720 vs BRIP1 — COAD

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