Isoprenoid metabolic process

Across TCGA patient cohorts, RNA activity of the Isoprenoid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMEM120A, RETSAT, and GIGYF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoprenoid metabolic process activity versus TMEM120A in UCEC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM120A →	+0.480	+0.307	.007	<.001	3	5
UCEC	RETSAT →	+0.547	+0.327	<.001	<.001	3	5
COAD	GIGYF1 →	-0.481	-0.377	<.001	<.001	3	4
PDAC	CDS1 →	+0.634	+0.234	<.001	<.001	3	4
LSCC	ERG28 →	+0.525	+0.245	<.001	<.001	3	4
PDAC	HSD17B12 →	+0.586	+0.268	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006720 vs TMEM120A — UCEC

Explore this scatter interactively →