Isoprenoid metabolic process

Across TCGA cell cohorts, RNA activity of the Isoprenoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTCH1, SCHIP1, and NPIPA8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTCH1 grouped by Isoprenoid metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PTCH1 →	-1.176	-0.449	.001	.004	3	4
BONE	SCHIP1 →	+2.170	+1.371	.005	.002	3	4
BONE	NPIPA8 →	-2.648	-1.280	.005	<.001	3	4
BLOOD_Leukemia	SCNN1D →	-0.907	-0.982	.007	.004	3	3
CNS	MAPK13 →	+1.102	+0.465	.001	.003	3	3
CNS	TEX22 →	-0.302	-0.487	.007	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTCH1 by Isoprenoid metabolic process activity — CNS

Explore this box plot interactively →