Isoprenoid metabolic process

Across TCGA cell cohorts, RNA activity of the Isoprenoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R12A, AMMECR1L, and NKTR, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoprenoid metabolic process activity versus PPP1R12A in LUNG_NSCLC_LUSC (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PPP1R12A →	-0.742	-0.093	.003	.005	3	11
STOMACH	AMMECR1L →	-0.657	-0.069	.008	.001	3	11
OVARY	NKTR →	-0.876	-0.062	.003	.009	2	12
BONE	KMT5B →	-1.006	-0.110	<.001	<.001	3	10
BLOOD_Leukemia	CLK1 →	-0.702	-0.065	<.001	<.001	3	10
LUNG_SCLC	ZNF431 →	-0.943	-0.100	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006720 vs PPP1R12A — LUNG_NSCLC_LUSC

Explore this scatter interactively →