Androgen catabolic process

Across TCGA patient cohorts, RNA activity of the Androgen catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, SLC11A1, and LUCAT1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Androgen catabolic process activity versus SPP1 in HNSC (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SPP1 →	+1.653	+1.152	<.001	<.001	3	8
BRCA	SLC11A1 →	+0.913	+1.359	<.001	<.001	3	8
CCRCC	LUCAT1 →	+1.258	+0.439	<.001	<.001	3	8
GBM	TREM1 →	+1.094	+0.380	.005	.003	2	8
GBM	OSCAR →	+0.759	+0.585	<.001	<.001	3	7
UCEC	IL4I1 →	+1.043	+0.413	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006710 vs SPP1 — HNSC

Explore this scatter interactively →