Mineralocorticoid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Mineralocorticoid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM3, MCM4, and SSC5D, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mineralocorticoid biosynthetic process activity versus MCM3 in GBM (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCM3 →	-0.516	-0.061	.008	.003	3	7
GBM	MCM4 →	-0.537	-0.060	.003	.004	3	7
CCRCC	SSC5D →	+0.770	+0.084	<.001	<.001	3	6
PDAC	C7 →	+0.454	+0.043	<.001	<.001	3	6
BRCA	CCL14 →	+0.514	+0.030	.005	.007	3	6
BRCA	EFEMP1 →	+0.454	+0.032	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006705 vs MCM3 — GBM

Explore this scatter interactively →