Mineralocorticoid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Mineralocorticoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAB2, LINC01094, and CDK14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mineralocorticoid biosynthetic process activity versus DAB2 in GBM (Pearson r = -0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DAB2 →	+0.790	+0.588	<.001	.003	3	5
CCRCC	LINC01094 →	+0.553	+0.695	<.001	<.001	3	4
BRCA	CDK14 →	+0.564	+0.532	.006	<.001	3	4
GBM	DSE →	+0.503	+0.794	.002	<.001	3	4
GBM	ADAMTS14 →	+0.898	+0.543	<.001	<.001	3	4
GBM	GSN →	+0.740	+0.556	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006705 vs DAB2 — GBM

Explore this scatter interactively →