Mineralocorticoid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Mineralocorticoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMCO1, CDKL1, and MAK16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMCO1 grouped by Mineralocorticoid biosynthetic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SMCO1 →	+0.075	+1.347	<.001	.008	3	4
LUNG_NSCLC_LUSC	CDKL1 →	-1.210	-1.323	.008	.004	3	3
LUNG_NSCLC_LUSC	MAK16 →	+0.940	+0.929	<.001	.006	3	3
PANCREAS	IVNS1ABP →	+1.024	+1.204	<.001	<.001	3	3
PANCREAS	MKKS →	+0.918	+0.928	<.001	.001	3	3
CNS	FRAS1 →	-1.680	-1.180	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMCO1 by Mineralocorticoid biosynthetic process activity — URINARY_TRACT

Explore this box plot interactively →